INTERLEUKIN-1 STIMULATES GLUCOSE-TRANSPORT IN RAT ADIPOSE-CELLS - EVIDENCE FOR RECEPTOR DISCRIMINATION BETWEEN IL-1-BETA AND IL-1-ALPHA

被引：41

作者：

GARCIAWELSH, A ^{[1
]}

SCHNEIDERMAN, JS ^{[1
]}

BALY, DL ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,DEPT NUTR,NEW BRUNSWICK,NJ 08903

来源：

FEBS LETTERS | 1990年 / 269卷 / 02期

关键词：

Cachexia; Cytokine; Glucose transport; Interleukin I-β; Interleukin I-β receptor;

D O I：

10.1016/0014-5793(90)81207-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of interleukin 1 (IL-1) on glucose transport activity in isolated rat adipose cells was examined. IL-1β stimulated 3-O-methylglucose (3OMG) transport in a time and dose dependent manner. This effect appears to be due to increased maximal transport velocity (Vmax of the carrier. Addition of insulin and IL-1β resulted in an additive stimulation of transport, suggesting different mechanisms. IL-1α had no effect on glucose transport. Glu-4, a relatively inactive IL-1β analogue in most cells, stimulated glucose uptake in a time and dose dependent manner with kinetics indistinguishable from those of IL- 1β. © 1990.

引用

页码：421 / 424

页数：4

共 30 条

[1]

BALY DL, 1987, J BIOL CHEM, V262, P21

[2] IMMUNOREGULATORY FEEDBACK BETWEEN INTERLEUKIN-1 AND GLUCOCORTICOID HORMONES [J].