HUMAN CARCINOMA-ASSOCIATED PRECURSOR ANTIGENS OF THE NM BLOOD-GROUP SYSTEM

被引:30
作者
SPRINGER, GF
DESAI, PR
MURTHY, MS
SCANLON, EF
机构
[1] NORTHWESTERN UNIV,DEPT SURG,EVANSTON,IL 60201
[2] NORTHWESTERN UNIV,DEPT MICROBIOL IMMUNOL,EVANSTON,IL 60201
关键词
anti‐T antibody; breast carcinoma; cell‐mediated immune response to T antigen; human adenocarcinoma‐associated antigen; immunodiagnosis; Thomsen‐Friedenreich (T) antigen;
D O I
10.1002/jso.2930110204
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Blood group NM specificities occur in healthy, benign and carcinomatous breast glands and those of the gastrointestinal (G.I.) tract, but the precursors in their biosynthesis, T (Thomsen‐Friedenreich) and Tn, are found in adenocarcinomata and not in benign or healthy tissues. T‐and Tn‐antigenic specificities are thus human carcinoma‐associated. All humans possess anti‐T and anti‐Tn antibodies. Patients with breast or G.I. tract carcinoma show statistically significant alteration of anti‐T titer levels when compared to patients with benign disease and to healthy controls. Breast carcinoma patients but not healthy people showed cellular immunity to T antigen in vitro and in vivo. Most striking was the delayed‐type hypersensitivity reaction, which was positive in over 90% of ductal breast carcinoma patients tested and negative in all presumably healthy individuals. T antigen is readily prepared from healthy human red blood cells in uncontaminated form, and free of HL‐A and Au antigens. T antigen and anti‐T antibodies may be useful in combating some human adenocarcinomata. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:95 / 106
页数:12
相关论文
共 54 条
[1]   BLOOD GROUP-LIKE ACTIVITY RELEASED BY HUMAN MAMMARY-CARCINOMA CELLS IN CULTURE [J].
ANGLIN, JH ;
LERNER, MP ;
NORDQUIST, RE .
NATURE, 1977, 269 (5625) :254-255
[2]   ANTIGENIC CROSS-REACTIVITY BETWEEN BENIGN AND MALIGNANT NEOPLASMS OF HUMAN BREAST [J].
AVIS, F ;
MOSONOV, I ;
HAUGHTON, G .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1974, 52 (04) :1041-1049
[3]  
BERMAN HJ, 1972, TRANSFUSION, V12, P35
[4]   INFLUENCE OF ORALLY-ADMINISTERED ANTIBIOTICS ON ANTI-T AGGLUTININ OF NORMAL SUBJECTS AND OF CIRRHOTIC PATIENTS [J].
BOCCARDI, V ;
ATTINA, D ;
GIRELLI, G .
VOX SANGUINIS, 1974, 27 (03) :268-272
[5]   The group-specific substances, A, B, M, N and Rh - Their occurrence in tissues and body fluids [J].
Boorman, KE ;
Dodd, BE .
JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1943, 55 (03) :329-339
[6]  
BURNET FM, 1946, BRIT J EXP PATHOL, V27, P228
[7]  
CANTRELL JL, UNPUBLISHED
[8]   TUBERCULIN-INDUCED MIGRATION INHIBITION OF HUMAN PERIPHERAL LEUCOCYTES IN AGAROSE MEDIUM [J].
CLAUSEN, JE .
ACTA ALLERGOLOGICA, 1971, 26 (01) :56-&
[9]   GLYCOPROTEIN COAT OF TA3 CELL - ISOLATION AND PARTIAL CHARACTERIZATION OF A SIALIC-ACID CONTAINING GLYCOPROTEIN FRACTION [J].
CODINGTON, JF ;
SANFORD, BH ;
JEANLOZ, RW .
BIOCHEMISTRY, 1972, 11 (14) :2559-+
[10]  
DAVIES DAL, 1966, IMMUNOLOGY, V11, P115