RECOMBINANT TRYPANOSOMA-CRUZI ANTIGENS AND CHAGAS-DISEASE DIAGNOSIS - ANALYSIS OF A WORKSHOP

被引：36

作者：

LEVIN, MJ

DASILVEIRA, JF

FRASCH, ACC

CAMARGO, ME

LAFON, S

DEGRAVE, WM

RANGELALDAO, R

机构：

[1] LAB FLEURY, SAO PAULO, BRAZIL

[2] ESCOLA PAULISTA MED SCH, DISCIPLINA PARASITOL, BR-04023 SAO PAULO, BRAZIL

[3] FDN CAMPOMAR, INST INVEST BIOQUIM, BUENOS AIRES, ARGENTINA

[4] FDN OSWALDO CRUZ, DEPT BIOL MOLEC, RIO DE JANEIRO, BRAZIL

[5] UNIV SIMON BOLIVAR, CARACAS, VENEZUELA

来源：

FEMS MICROBIOLOGY IMMUNOLOGY | 1991年 / 89卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

TRYPANOSOMA-CRUZI; DIAGNOSIS; CHAGAS DISEASE; TRYPANOSOMA-CRUZI RECOMBINANT ANTIGENS; IMMUNOASSAY;

D O I：

10.1016/0378-1097(91)90058-I

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A workshop organized by the Ibero-American Project of Biotechnology evaluated the diagnostic potential of several cloned Trypanosoma cruzi recombinant antigens for Chagas' disease serodiagnosis. A set of recombinants, Antigen 2, Antigen 13, SAPA, H49, A13, JL5, JL7, JL8, JL9, and RA1 provided by three different South American laboratories were probed with a panel of 236 South American serum samples. Antigens JL7, H49, Antigen 2, and A13 scored as the best diagnostic recombinant reagents. The results suggested that the main advantage of using cloned peptides for chronic Chagas' disease diagnosis resided in their highly specific immunoreactive properties.

引用

页码：11 / 19

页数：9

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