KALLMANN SYNDROME GENE ON THE X-CHROMOSOME AND Y-CHROMOSOMES - IMPLICATIONS FOR EVOLUTIONARY DIVERGENCE OF HUMAN SEX-CHROMOSOMES

被引：43

作者：

INCERTI, B

GUIOLI, S

PRAGLIOLA, A

ZANARIA, E

BORSANI, G

TONLORENZI, R

BARDONI, B

FRANCO, B

WHEELER, D

BALLABIO, A

CAMERINO, G

机构：

[1] UNIV PAVIA, I-27100 PAVIA, ITALY

[2] BAYLOR COLL MED, INST MOLEC GENET, HOUSTON, TX 77030 USA

[3] BAYLOR COLL MED, DEPT CELL BIOL, HOUSTON, TX 77030 USA

[4] IST GIANNINA GASLINI, I-16148 GENOA, ITALY

来源：

NATURE GENETICS | 1992年 / 2卷 / 04期

关键词：

D O I：

10.1038/ng1292-311

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The recently identified gene for X-linked Kallmann syndrome (hypogonadotropic hypogonadism and anosmia) has a closely related homologue on the Y chromosome. The X and Y copies of this gene are located in a large region of X/Y homology, on Xp22.3 and Yq11.2, respectively. Comparison of the structure of the X-linked Kallmann syndrome gene and its Y homologue shed light on the evolutionary history of this region of the human sex chromosomes. Our data show that the Y homologue is not functional. Comparative analysis of X/Y sequence identity at several loci on Xp22.3 and Yq11.2 suggests that the homology between these two regions is the result of a complex series of events which occurred in the recent evolution of sex chromosomes.

引用

页码：311 / 314

页数：4

共 30 条

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