EVOLUTION OF SEX DETERMINATION AND THE Y-CHROMOSOME - SRY-RELATED SEQUENCES IN MARSUPIALS

被引：196

作者：

FOSTER, JW

BRENNAN, FE

HAMPIKIAN, GK

GOODFELLOW, PN

SINCLAIR, AH

LOVELLBADGE, R

SELWOOD, L

RENFREE, MB

COOPER, DW

GRAVES, JAM

机构：

[1] LA TROBE UNIV,DEPT GENET & HUMAN VARIAT,BUNDOORA,VIC 3083,AUSTRALIA

[2] IMPERIAL CANC RES FUND,HUMAN MOLEC GENET LAB,LONDON WC2A 3PX,ENGLAND

[3] NATL INST MED RES,MRC,EUKARYOT MOLEC GENET LAB,LONDON NW7 1AA,ENGLAND

[4] LA TROBE UNIV,DEPT ZOOL,BUNDOORA,VIC 3083,AUSTRALIA

[5] UNIV MELBOURNE,DEPT ZOOL,PARKVILLE,VIC 3052,AUSTRALIA

[6] MACQUARIE UNIV,SCH BIOL SCI,N RYDE,NSW 2109,AUSTRALIA

来源：

NATURE | 1992年 / 359卷 / 6395期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/359531a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

IN mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome1,2. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man3-5 and mouse6,7. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ube1y homologues8, are the first genes to be identified on the marsupial Y chromosome.

引用

页码：531 / 533

页数：3

共 20 条

[1] GENETIC-EVIDENCE EQUATING SRY AND THE TESTIS-DETERMINING FACTOR [J].