ALZHEIMERS-DISEASE - A SPIROCHETOSIS

被引：126

作者：

MIKLOSSY, J

机构：

[1] University Institute of Pathology, Division of Neuropathology, University of Lausanne, Lausanne, 1005

来源：

NEUROREPORT | 1993年 / 4卷 / 07期

关键词：

ALZHEIMERS DISEASE; AMYLOID; AMYLOID PRECURSOR PROTEIN; BETA AMYLOID PROTEIN; SPIROCHETAL DISEASE;

D O I：

10.1097/00001756-199307000-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE aetiology of Alzheimer's disease (AD), which affects a large proportion of the aged population is unknown and the treatment unresolved. The role of beta amyloid protein (betaA4), derived from a larger amyloid precursor protein (APP) in AD is the subject of intense research. Here I report observations that in 14 autopsy cases with histopathologically confirmed AD, spirochetes were found in blood and cerebrospinal fluid and, moreover, could be isolated from brain tissue. Thirteen age-matched control cases were without spirochetes. Reference strains of spirochetes and those isolated from brains of AD patients, showed positive immunoreaction with monoclonal antibody against the beta amyloid precursor protein. These observations suggest that spirochetes may be one of the causes of AD and that they may be the source of the beta amyloid deposited in the AD brain.

引用

页码：841 / 848

页数：8

共 31 条

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[2] LOCALIZATION OF AMYLOID BETA-PROTEIN MESSENGER-RNA IN BRAINS FROM PATIENTS WITH ALZHEIMERS-DISEASE [J].