SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE-CHAIN

被引：7

作者：

OKITA, T ^{[1
]}

IMAE, K ^{[1
]}

HASEGAWA, T ^{[1
]}

IMURA, S ^{[1
]}

MASUYOSHI, S ^{[1
]}

KAMACHI, H ^{[1
]}

KAMEI, H ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB RES INST,MEGURO KU,TOKYO 153,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 05期

关键词：

D O I：

10.7164/antibiotics.46.833

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

CePhalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-1-propen-1-yl]cephalosporin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia.

引用

页码：833 / 839

页数：7

共 11 条

[1]

CORBETT DF, 1988, Patent No. 152389

[2] SYNTHESIS OF GEOMETRICAL-ISOMERS OF 3-(3-ACETOXY-1-PROPENYL)CEPHALOSPORIN AND 3-(3-CARBAMOYLOXY-1-PROPENYL)CEPHALOSPORIN AND THEIR STRUCTURE-ACTIVITY-RELATIONSHIPS [J].

KAMACHI, H ;

OKITA, T ;

HOSHI, H ;

OKUYAMA, S ;

NAITO, T .

JOURNAL OF ANTIBIOTICS, 1992, 45 (06) :998-1001

[3] SYNTHESIS OF A NEW SERIES OF CEPHALOSPORINS HAVING 3-SUBSTITUTED-AMMONIO-1-PROPENYL GROUP AS THE C-3 SIDE-CHAIN [J].

KAMACHI, H ;

OKA, M ;

NARITA, Y ;

IIMURA, S ;

ABURAKI, S ;

YAMASHITA, H ;

TOMATSU, K ;

OKUMURA, J ;

NAITO, T .

JOURNAL OF ANTIBIOTICS, 1990, 43 (05) :533-543

[4] INVITRO ANTIBACTERIAL ACTIVITY OF E-0702, A NEW SEMI-SYNTHETIC CEPHALOSPORIN [J].

KATSU, K ;

KITOH, K ;

INOUE, M ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 22 (02) :181-185

[5] ANTIBACTERIAL AND PHARMACOKINETIC PROPERTIES OF M14659, A NEW INJECTABLE SEMISYNTHETIC CEPHALOSPORIN [J].

MOCHIZUKI, H ;

OIKAWA, Y ;

YAMADA, H ;

KUSAKABE, S ;

SHIIHARA, T ;

MURAKAMI, K ;

KATO, K ;

ISHIGURO, J ;

KOSUZUME, H .

JOURNAL OF ANTIBIOTICS, 1988, 41 (03) :377-391

[6] BACTERICIDAL ACTIVITY OF M14659 ENHANCED IN LOW-IRON ENVIRONMENTS [J].

MOCHIZUKI, H ;

YAMADA, H ;

OIKAWA, Y ;

MURAKAMI, K ;

ISHIGURO, J ;

KOSUZUME, H ;

AIZAWA, N ;

MOCHIDA, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (11) :1648-1654

[7] INVITRO AND INVIVO ANTIBACTERIAL ACTIVITIES OF BO-1341, A NEW ANTIPSEUDOMONAL CEPHALOSPORIN [J].

NAKAGAWA, S ;

SANADA, M ;

MATSUDA, K ;

HASHIZUME, T ;

ASAHI, Y ;

USHIJIMA, R ;

OHTAKE, N ;

TANAKA, N .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (09) :1423-1427

[8] BIOLOGICAL-ACTIVITY OF BO-1236, A NEW ANTIPSEUDOMONAL CEPHALOSPORIN [J].

NAKAGAWA, S ;

SANADA, M ;

MATSUDA, K ;

HAZUMI, N ;

TANAKA, N .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (07) :1100-1105

[9]

SANADA M, 1988, DRUG EXP CLIN RES, V14, P397

[10] E-0702, A NEW CEPHALOSPORIN, IS INCORPORATED INTO ESCHERICHIA-COLI-CELLS VIA THE TONB-DEPENDENT IRON TRANSPORT-SYSTEM [J].

WATANABE, NA ;

NAGASU, T ;

KATSU, K ;

KITOH, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (04) :497-504

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