THE ASYMMETRIC-SYNTHESIS OF BOTH ENANTIOMERS OF ELIPRODIL

被引：13

作者：

DIFABIO, R ^{[1
]}

PIETRA, C ^{[1
]}

THOMAS, RJ ^{[1
]}

ZIVIANI, L ^{[1
]}

机构：

[1] GLAXO SPA,GLAXO RES LABS,I-37135 VERONA,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 06期

关键词：

D O I：

10.1016/0960-894X(95)00071-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The asymmetric synthesis of both enantiomers of the racemic NMDA antagonist eliprodil was accomplished in a novel application of Sharpless' asymmetric dihydroxylation (AD) methodology. A difference in neuroprotective activity was noted for the enantiomers in an in vivo model of rat focal cerebral ischemia.

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收藏

页码：551 / 554

页数：4

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