BETA-CYCLODEXTRIN INTERACTS WITH THE ALZHEIMER AMYLOID BETA-A4 PEPTIDE

被引：111

作者：

CAMILLERI, P ^{[1
]}

HASKINS, NJ ^{[1
]}

HOWLETT, DR ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

FEBS LETTERS | 1994年 / 341卷 / 2-3期

关键词：

AMYLOID; A4; PEPTIDE; ALZHEIMERS DISEASE; BETA-CYCLODEXTRIN; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; FIBRILLISATION;

D O I：

10.1016/0014-5793(94)80467-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid beta-amyloid peptide (beta1-40) interacts with the cyclic oligosaccharide beta-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of beta1-40 in a cell line.

引用

页码：256 / 258

页数：3

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