A GENE STRUCTURE OF TESTOSTERONE 6-BETA-HYDROXYLASE (P450IIIA)

被引：21

作者：

MIYATA, M ^{[1
]}

NAGATA, K ^{[1
]}

YAMAZOE, Y ^{[1
]}

KATO, R ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT PHARMACOL,35 SHINANOMACHI,SHINJUKU KU,TOKYO 108,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)91949-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic clones of a rat testosterone 6β-hydroxylase have been isolated and characterized as the first gene ( P450 6βA) among P450IIIA subfamily. This gene spans about 25Kb and consists of 13 exons, which is the largest number of exons among cytochrome P-450 genes reported previously. The nucleotide sequence of the exon region showed high similarity to those of P450PCN2 and P450PCN1 cDNA (Gonzalez, F. J. et al. (1987) Mol. Cell. Biol. 2969-2974), but several replacements and deletions of nucleotide were found between the P450 6βA gene and both cDNAs, indicating the existence of multiple P450IIIA genes in rats. © 1991.

引用

页码：68 / 73

页数：6

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