PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF PEDIATRIC BRAIN-TUMORS

被引：88

作者：

SUTTON, LN

WANG, ZY

GUSNARD, D

LANGE, B

PERILONGO, G

BOGDAN, AR

DETRE, JA

RORKE, L

ZIMMERMAN, RA

机构：

[1] CHILDRENS HOSP PHILADELPHIA,DEPT NEUROPATHOL,PHILADELPHIA,PA 19104

[2] CHILDRENS HOSP PHILADELPHIA,DEPT NEURORADIOL,PHILADELPHIA,PA 19104

[3] CHILDRENS HOSP PHILADELPHIA,NEUROONCOL GRP,PHILADELPHIA,PA 19104

[4] UNIV PENN,SCH MED,DEPT BIOCHEM & BIOPHYS,PHILADELPHIA,PA 19104

[5] UNIV PENN,SCH MED,DEPT RADIOL,PHILADELPHIA,PA 19104

[6] UNIV PENN,SCH MED,DEPT PEDIAT,PHILADELPHIA,PA 19104

[7] UNIV PENN,SCH MED,DEPT PATHOL & NEUROPATHOL,PHILADELPHIA,PA 19104

[8] UNIV PENN,SCH MED,DEPT NEUROSURG,PHILADELPHIA,PA 19104

[9] SIEMENS MED SYST ARB,ISOLEN,NJ

来源：

NEUROSURGERY | 1992年 / 31卷 / 02期

关键词：

ASTROCYTOMA; BRAIN TUMOR; GLIOMA; MEDULLOBLASTOMA; NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY;

D O I：

10.1227/00006123-199208000-00004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

H-1 MAGNETIC RESONANCE spectroscopy allows the regional quantitation of a number of metabolites from the brain in a noninvasive fashion. Spectra were obtained from 5 normal children and 25 children with brain tumors. Choline (Cho), N-acetylaspartate (NAA), creatine and phosphocreatine, and lactate were quantitated in the form of ratios. The brains of normal children showed relatively high concentrations of Cho and NAA and virtually no lactate, as has been shown in adults. Benign astrocytomas and ependymomas were characterized by an elevation of the Cho:NAA ratio and an abnormal accumulation of lactate. Intrinsic malignant tumors were remarkable for an even higher Cho:NAA ratio but had no more lactate than was found in the benign tumors. Proton magnetic resonance spectroscopy may prove useful in characterizing neoplastic tissue in conjunction with more conventional imaging modalities.

引用

页码：195 / 202

页数：8

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