INVIVO EFFECTS OF CADMIUM ON RAT-LIVER GLUCOCORTICOID RECEPTOR FUNCTIONAL-PROPERTIES

被引：14

作者：

DUNDERSKI, J ^{[1
]}

STANOSEVIC, J ^{[1
]}

RISTIC, B ^{[1
]}

TRAJKOVIC, D ^{[1
]}

MATIC, G ^{[1
]}

机构：

[1] SINISA STANKOVIC INST BIOL RES, DEPT ECOL, YU-11000 BELGRADE, YUGOSLAVIA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 07期

关键词：

D O I：

10.1016/0020-711X(92)90375-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Cadmium (Cd2+) administered in vivo induced a 40% reduction of rat liver glucocorticoid receptor (GR) capacity and inhibition of glucocorticoid-receptor complexes binding to mouse mammary tumor virus (MMTV) DNA fragment containing GR consensus sequence. 2. The effect of Cd2+ on the GR binding activity can be reversed with DTT, suggesting Cd2+ interaction with thiol groups. 3. Cd2+-related GR modification seems to be mediated by Cd2+ binding to cytoplasmic components included in the regulation of the receptor function, although the direct binding of the metal to the receptor thiols could not be ruled out.

引用

页码：1065 / 1072

页数：8

共 32 条

[1] PROTECTION AGAINST CADMIUM TOXICITY AND ENZYME-INHIBITION BY DITHIOTHREITOL [J].

AHAMMADSAHIB, KI ;

JINNA, RR ;

DESAIAH, D .

CELL BIOCHEMISTRY AND FUNCTION, 1989, 7 (03) :185-192

[2]

BEATO M, 1972, J BIOL CHEM, V247, P7890

[3] INHIBITION OF GLUCOCORTICOID RECEPTOR TRANSFORMATION, SUBUNIT DISSOCIATION, AND TEMPERATURE-DEPENDENT INACTIVATION BY VARIOUS N-SUBSTITUTED MALEIMIDES [J].

BLICQ, S ;

DANZE, PM ;

DUMUR, V ;

FORMSTECHER, P ;

DAUTREVAUX, M .

BIOCHEMISTRY, 1988, 27 (22) :8436-8442

[4] SULFHYDRYL-MODIFYING REAGENTS REVERSIBLY INHIBIT BINDING OF GLUCOCORTICOID RECEPTOR COMPLEXES TO DNA-CELLULOSE [J].

BODWELL, JE ;

HOLBROOK, NJ ;

MUNCK, A .

BIOCHEMISTRY, 1984, 23 (07) :1392-1398

[5] EVIDENCE FOR DISTINCT SULFHYDRYL-GROUPS ASSOCIATED WITH STEROID-BINDING AND DNA-BINDING DOMAINS OF RAT THYMUS GLUCOCORTICOID RECEPTORS [J].

BODWELL, JE ;

HOLBROOK, NJ ;

MUNCK, A .

BIOCHEMISTRY, 1984, 23 (18) :4237-4242

[6] DIFFERENTIAL EXPRESSION OF HEAT-SHOCK PROTEINS IN DROSOPHILA EMBRYONIC-CELLS FOLLOWING METAL-ION EXPOSURE [J].

BOURNIASVARDIABASIS, N ;

BUZIN, C ;

FLORES, J .

EXPERIMENTAL CELL RESEARCH, 1990, 189 (02) :177-182

[7] HYDROGEN-PEROXIDE STABILIZES THE STEROID-BINDING STATE OF RAT-LIVER GLUCOCORTICOID RECEPTORS BY PROMOTING DISULFIDE BOND FORMATION [J].

BRESNICK, EH ;

SANCHEZ, ER ;

HARRISON, RW ;

PRATT, WB .

BIOCHEMISTRY, 1988, 27 (08) :2866-2872

[8] THE HORMONE REGULATORY ELEMENT OF MOUSE MAMMARY-TUMOR VIRUS MEDIATES PROGESTERONE INDUCTION [J].

CATO, ACB ;

MIKSICEK, R ;

SCHUTZ, G ;

ARNEMANN, J ;

BEATO, M .

EMBO JOURNAL, 1986, 5 (09) :2237-2240

[9]

CHOWDHURY BA, 1987, PROG FOOD NUTR SCI, V11, P55

[10] ZINC POTENTIATION OF ANDROGEN RECEPTOR-BINDING TO NUCLEI INVITRO [J].

COLVARD, DS ;

WILSON, EM .

BIOCHEMISTRY, 1984, 23 (15) :3471-3478

← 1 2 3 4 →