ENHANCED GABA RELEASE IN CEREBRAL CORTICAL SLICES DERIVED FROM RATS WITH THIOACETAMIDE-INDUCED HEPATIC-ENCEPHALOPATHY

被引:27
作者
WYSMYK, U
OJA, SS
SARANSAARI, P
ALBRECHT, J
机构
[1] POLISH ACAD SCI,MED RES CTR,3 DWORKOWA STR,PL-00784 WARSAW,POLAND
[2] UNIV TAMPERE,DEPT BIOMED SCI,TAMPERE BRAIN RES CTR,SF-33101 TAMPERE,FINLAND
关键词
HEPATIC ENCEPHALOPATHY; THIOACETAMIDE; CEREBRAL CORTEX; GABA RELEASE;
D O I
10.1007/BF00968397
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The release of newly loaded [H-3]GABA was studied in slices of different brain regions derived from rats in which acute hepatic encephalopathy (HE) was induced with a hepatotoxin thioacetamide. HE increased both spontaneous and high (50 mM) ammonium chloride-evoked GABA release in cerebral cortical slices by 38% and 50%, respectively. No effects of HE were noted in cerebellar or striatal slices. An increased release of GABA in the cerebral cortex may contribute to the endogenous benzodiazepine-mediated enhancement of GABAergic tone, which is thought to be partly responsible for the pathophysiological mechanism of HE.
引用
收藏
页码:1187 / 1190
页数:4
相关论文
共 14 条
[1]   BRAIN CARBONIC-ANHYDRASE ACTIVITY IN RATS IN EXPERIMENTAL HEPATOGENIC ENCEPHALOPATHY [J].
ALBRECHT, J ;
HILGIER, W .
NEUROSCIENCE LETTERS, 1984, 45 (01) :7-10
[2]   ENHANCED POTASSIUM-STIMULATED GAMMA-AMINOBUTYRIC-ACID RELEASE BY ASTROCYTES DERIVED FROM RATS WITH EARLY HEPATOGENIC ENCEPHALOPATHY [J].
ALBRECHT, J ;
RAFALOWSKA, U .
JOURNAL OF NEUROCHEMISTRY, 1987, 49 (01) :9-11
[3]  
ALBRECHT J, 1988, BIOCH PATHOLOGY ASTR, P465
[4]   GABAA RECEPTOR COMPLEX IN AN EXPERIMENTAL-MODEL OF HEPATIC-ENCEPHALOPATHY - EVIDENCE FOR ELEVATED LEVELS OF AN ENDOGENOUS BENZODIAZEPINE RECEPTOR LIGAND [J].
BASILE, AS ;
GAMMAL, SH ;
JONES, EA ;
SKOLNICK, P .
JOURNAL OF NEUROCHEMISTRY, 1989, 53 (04) :1057-1063
[5]   EVIDENCE FOR THE INVOLVEMENT OF THE BENZODIAZEPINE RECEPTOR COMPLEX IN HEPATIC-ENCEPHALOPATHY [J].
BASILE, AS ;
GAMMAL, SH .
CLINICAL NEUROPHARMACOLOGY, 1988, 11 (05) :401-422
[6]   THE CONTRIBUTION OF ENDOGENOUS BENZODIAZEPINE RECEPTOR LIGANDS TO THE PATHOGENESIS OF HEPATIC-ENCEPHALOPATHY [J].
BASILE, AS .
SYNAPSE, 1991, 7 (02) :141-150
[7]  
DIAZMUNOZ M, 1988, NEUROCHEM RES, V13, P227
[8]   EFFLUX OF PHENYLALANINE FROM RAT CEREBRAL-CORTEX SLICES AS INFLUENCED BY EXTRACELLULAR AND INTRACELLULAR AMINO-ACIDS [J].
KORPI, ER ;
OJA, SS .
JOURNAL OF NEUROCHEMISTRY, 1979, 32 (03) :789-796
[9]   EFFECT OF AMINOOXYACETIC ACID ON THE RELEASE OF PRELOADED [H-3]GABA AND RADIOACTIVE METABOLITES FROM SLICES OF DEVELOPING MOUSE-BRAIN [J].
OJA, SS ;
KONTRO, P .
NEUROCHEMICAL RESEARCH, 1988, 13 (10) :923-928
[10]   BRAIN CORTICAL AMINO-ACIDS MEASURED BY INTRACEREBRAL DIALYSIS IN PORTACAVAL SHUNTED RATS [J].
TOSSMAN, U ;
DELIN, A ;
ERIKSSON, LS ;
UNGERSTEDT, U .
NEUROCHEMICAL RESEARCH, 1987, 12 (03) :265-269