A CONVENIENT SOLID-PHASE PREPARATION OF PEPTIDE SUBSTITUTED AMIDES

被引：45

作者：

VOYER, N

LAVOIE, A

PINETTE, M

BERNIER, J

机构：

[1] Département de chimie, Université de Sherbrooke, Sherbrooke

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0040-4039(94)85052-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of the title compounds by a solid phase procedure is reported. The method involves the incorporation of different amines at the C-terminal position of a peptide molecule by its nucleophilic displacement from the oxime resin. The method works well with primary aliphatic and aromatic amines but gives lower yields with deactivated or sterically hindered amines.

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页码：355 / 358

页数：4

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