BIOLOGICAL AND PHYTOCHEMICAL EVALUATION OF PLANTS .V. ISOLATION OF 2 CYTOTOXIC ALKALOIDS FROM CHELIDONIUM MAJUS

被引:18
作者
KIM, HK
FARNSWORTH, NR
BLOMSTER, RN
FONG, HHS
机构
[1] Department of Pharmacognosy, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania
[2] Department of Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore, Maryland
关键词
Chelidonium majus—alkaloids; isolation; Coptisine; C; majus—isolated; identified; Cytotoxicity—C. majus alkaloids; IR spectrophotometry—identity; Mass spectroscopy—identity; TLC—separation; identity; UV spectrophotometry—identity;
D O I
10.1002/jps.2600580323
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A routine screening of randomly selected native plants for biological activity revealed that an extract from Chelidonium majus elicited significant cytotoxicity, but was devoid of antitumor properties. A subsequent investigation of the alkaloids from this plant resulted in the isolation of coptisine as the chloride. Coptisine chloride and a second new alkaloid have been shown to be two of the cytotoxic principles of Chelidonium majus. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:372 / +
页数:1
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