BIOLOGICAL AND PHYTOCHEMICAL EVALUATION OF PLANTS .V. ISOLATION OF 2 CYTOTOXIC ALKALOIDS FROM CHELIDONIUM MAJUS

被引：18

作者：

KIM, HK

FARNSWORTH, NR

BLOMSTER, RN

FONG, HHS

机构：

[1] Department of Pharmacognosy, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania

[2] Department of Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore, Maryland

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 03期

关键词：

Chelidonium majus—alkaloids; isolation; Coptisine; C; majus—isolated; identified; Cytotoxicity—C. majus alkaloids; IR spectrophotometry—identity; Mass spectroscopy—identity; TLC—separation; identity; UV spectrophotometry—identity;

D O I：

10.1002/jps.2600580323

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A routine screening of randomly selected native plants for biological activity revealed that an extract from Chelidonium majus elicited significant cytotoxicity, but was devoid of antitumor properties. A subsequent investigation of the alkaloids from this plant resulted in the isolation of coptisine as the chloride. Coptisine chloride and a second new alkaloid have been shown to be two of the cytotoxic principles of Chelidonium majus. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：372 / +

页数：1

共 32 条

[1]

AMINEV A M, 1960, Vopr Onkol, V6(8), P81

[2]

AWE W, 1951, ARZNEIMITTEL-FORSCH, V7, P287

[3] ALKALOIDS OF CHELIDONIUM-MAJUS, L, LEAVES AND STEMS .1. DL-TETRAHYDROCOPTISINE [J].

BANDELIN, FJ ;

MALESH, W .

JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1956, 45 (10) :702-704

[4]

BEREZKINA FI, 1896, VRACHEBNOE ZAP, V3, P195

[5]

BODALSKI T., 1957, DISSERTATIONES PHARMACEUT, V9, P157

[6]

BODALSKI T., 1958, ARCH IMMUNOLOGII I TERAPII DOSWIADCZALNEJ, V6, P705

[7]

BODALSKI TADEUSZ, 1957, DISSERTATIONES PHARMACEUE, V9, P265

[8]

BODALSKI TODEUZ, 1957, DISSERTATIONES PHARMACEUT, V9, P273

[9]

BOTKIN ES, 1896, B GAZ BOTKINA, V7, P1190

[10]

DEMCHENKO PF, 1957, VRACHEBN DELO, V12, P1335

← 1 2 3 4 →