CONCENTRATIONS OF HYDROCARBONS IN TISSUES AS A MEASURE OF TOXICITY

被引：51

作者：

SHUGAEV, BB

机构：

[1] Department of Pharmacology, Yaroslavl Medical Institute, USSR, Yaroslavl

[2] Fairleigh Dickinson University, Teaneck, NJ

来源：

ARCHIVES OF ENVIRONMENTAL HEALTH | 1969年 / 18卷 / 06期

关键词：

D O I：

10.1080/00039896.1969.10665509

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Mice and rats were exposed of vapors of butane, butadiene, isoprene, isobutylene, hexenes, and styrene. The concentrations of hydrocarbons in tissues after exposure were determined by gas liquid chromatography. Lethal concentration (LC50) values for two- and four-hour exposures, and the corresponding LC50 in brain tissues were determined for several hydrocarbons. The hydrocarbon concentration found in the brain correlated with the degree of central nervous system depression and narcosis. Mixtures of butane and isobutylene had a potentiating effect in 10 of 12 experiments, and an additive effect in two experiments. © 1969 Taylor & Francis Group, LLC.

引用

页码：878 / &

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