SUPER-SENSITIVITY TO OPIOIDS FOLLOWING THE CHRONIC BLOCKADE OF ENDORPHIN ACTION BY NALOXONE

被引：110

作者：

SCHULZ, R

WUSTER, M

HERZ, A

机构：

[1] Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, München 40, D-8000

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1979年 / 306卷 / 01期

关键词：

Guinea-pig ileum; Naloxone; Opiate receptors; Supersensitivity;

D O I：

10.1007/BF00515600

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic treatment of guinea pigs with the narcotic antagonist naloxone (pellet implantation technique) caused an increased sensitivity to opioids of the electrically stimulated longitudinal muscle-myenteric plexus preparation of the ileum. This supersensitivity is associated with an elevation of the total number of opiate receptor binding sites in both the peripheral and the central nervous system. © 1979 Springer-Verlag.

引用

页码：93 / 96

页数：4

共 19 条

[1]

Gibson R D, 1970, J Pharm Sci, V59, P426, DOI 10.1002/jps.2600590338

[2]

HERZ A, 1978, MECHANISMS PAIN ANAL

[3]

HITZEMANN RJ, 1974, LIFE SCI, V14, P2392

[4] COMPARISON OF INVIVO AND INVITRO PARAMETERS OF OPIATE RECEPTOR-BINDING IN NAIVE AND TOLERANT-DEPENDENT RODENTS [J].