QUINOLONE RESISTANCE-DETERMINING REGION IN THE DNA GYRASE GYRA GENE OF ESCHERICHIA-COLI

被引：551

作者：

YOSHIDA, H

BOGAKI, M

NAKAMURA, M

NAKAMURA, S

机构：

[1] Research Laboratories, Dainippon Pharmac. Co., Ltd., Osaka 564

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 06期

关键词：

D O I：

10.1128/AAC.34.6.1271

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

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页码：1271 / 1272

页数：2

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