Carbaryl, when administered during organogenesis at a level of 300 mg/kg, was teratogenic in the guinea pig; however, no terata were produced in hamsters at the sublethal levels of 125 and 250 mg/kg. In rabbits, carbaryl at 50-200 mg/kg (levels not producing any mortality or morbidity as in the hamster or guinea pig) did not produce terata. Diazinon was not found to be teratogenic in either the rabbit at 7 or 30 mg/kg or the hamster at 0.125 or 0.25 mg/kg. The higher level of diazinon given to the rabbit and both levels of diazinon and carbaryl given to the hamster produced cholinergic signs. Norea was not teratogenic or embryotoxic in the hamster when administered at 2 g/kg in a single dose or at this level for 5 consecutive days. The teratogenicity of DMSO in the hamster at 1 ml/100 g body weight was confirmed. Thiram was teratogenic when suspended in carboxymethyl cellulose (CMC) at 250 mg/kg; when it was dissolved in DMSO, the teratogenicity was additive or possibly more than additive. When DMSO was used as a solvent for disulfiram, the high levels of disulfiram were more teratogenic than was DMSO alone. Disulfiram as a CMC suspension was not teratogenic. At the high doses administered in these experiments, some compounds (e.g., diazinon and carbaryl in the rabbit) affected only the mother while others were at least equally toxic for the fetus and affected organogenesis. © 1969.
