RECURRING THEME OF CHANGES IN THE TRANSCRIPTIONAL CONTROL REGION OF BK-VIRUS DURING ADAPTATION TO CELL-CULTURE

被引：50

作者：

RUBINSTEIN, R

SCHOONAKKER, BCA

HARLEY, EH

机构：

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 03期

关键词：

D O I：

10.1128/JVI.65.3.1600-1604.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

BK virus, when cloned directly from human urine, shows no amplification in the transcriptional control region, unlike cell culture-passaged strains, but possesses an additional sequence element. To confirm our proposal that this represents the archetypal in vivo form of the virus, we passaged this BK virus through cell culture. Changes in the transcriptional control region occurred as early as the first passage and were characterized in all cases by a deletion followed by amplification events.

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页码：1600 / 1604

页数：5

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