MONTMORILLONITE SUPPORTED (-)-N-DODECYL-N-METHYL-EPHEDRENIUM BOROHYDRIDE - AN EFFICIENT REDUCING AGENT

被引：9

作者：

SARKAR, A

RAO, BR

机构：

[1] Deptt. of Appl. Chemistry, Indian School of Mines, Dhanbad

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(00)92057-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The clay supported reagent reduces ketones under phase transfer conditions efficiently. A two fold activation of the carbonyl group - one by the Lewis acid sites on clay and the other by the beta-hydroxy group of ephedrenium moiety, ensures facile reductions - maintaining a fair degree of stereoselectivity in reducing some of the cyclic ketones. Asymmetric inductions of 1-9.7% were observed in case of some prochiral ketones.

引用

页码：1247 / 1250

页数：4

共 6 条

[1]

COLONNA S, 1975, SYNTHESIS-STUTTGART, P531

[2]

GRIMSHAW RE, 1971, CHEM PHYSICS CLAYS

[3]

MCKILLOP A, 1979, SYNTHESIS-STUTTGART, P401

[4] MONTMORILLONITE SUPPORTED BOROHYDRIDE - A NEW REDUCING AGENT FOR REDUCTIONS UNDER PHASE-TRANSFER CONDITIONS [J].