INHIBITION OF ACETYLCHOLINESTERASE BY CAFFEINE, ANABASINE, METHYL PYRROLIDINE AND THEIR DERIVATIVES

被引：32

作者：

KARADSHEH, N ^{[1
]}

KUSSIE, P ^{[1
]}

LINTHICUM, DS ^{[1
]}

机构：

[1] UNIV TEXAS, HLTH SCI CTR, HOUSTON, TX 77225 USA

来源：

TOXICOLOGY LETTERS | 1991年 / 55卷 / 03期

关键词：

ACETYLCHOLINE ESTERASE; CAFFEINE; ALKALOIDS; ENZYME INHIBITION;

D O I：

10.1016/0378-4274(91)90015-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined. Most of the compounds had moderate inhibitory activity with I50 values in the range of 87-480-mu-M. The inhibition of AChE by these compounds has not been previously reported. A structural feature common to these compounds is the N-methyl determinant of the pyrrolidine ring which may be important in binding to the AChE.

引用

收藏

页码：335 / 342

页数：8

相关论文

共 14 条

[1] CHARACTERIZATION OF A PURIFIED NICOTINIC RECEPTOR FROM RAT-BRAIN BY USING IDIOTYPIC AND ANTIIDIOTYPIC ANTIBODIES [J].

ABOOD, LG ;

LANGONE, JJ ;

BJERCKE, R ;

LU, X ;

BANERJEE, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (18) :6587-6590

[2] STEREOSPECIFIC MONOCLONAL-ANTIBODIES TO NICOTINE AND COTININE AND THEIR USE IN ENZYME-LINKED IMMUNOSORBENT ASSAYS [J].

BJERCKE, RJ ;

COOK, G ;

RYCHLIK, N ;

GJIKA, HB ;

VANVUNAKIS, H ;

LANGONE, JJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 1986, 90 (02) :203-213

[3] COMPARISON OF MONOCLONAL AND POLYCLONAL ANTIBODIES TO COTININE IN NONISOTOPIC AND ISOTOPIC IMMUNOASSAYS [J].

BJERCKE, RJ ;

COOK, G ;

LANGONE, JJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 96 (02) :239-246

[4] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[5] REVERSIBLE INHIBITION OF ACETYLCHOLINESTERASE BY ESEROLINE, AN OPIOID AGONIST STRUCTURALLY RELATED TO PHYSOSTIGMINE (ESERINE) AND MORPHINE [J].

GALLI, A ;

RENZI, G ;

GRAZZINI, E ;

BARTOLINI, R ;

AIELLOMALMBERG, P ;

BARTOLINI, A .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (07) :1233-1238

[6] CATALYTIC ANTIBODIES [J].

JACOBS, J ;

SCHULTZ, PG ;

SUGASAWARA, R ;

POWELL, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (07) :2174-2176

[7] INDUCTION OF AN ANTIBODY THAT CATALYZES THE HYDROLYSIS OF AN AMIDE BOND [J].

JANDA, KD ;

SCHLOEDER, D ;

BENKOVIC, SJ ;

LERNER, RA .

SCIENCE, 1988, 241 (4870) :1188-1191

[8] INHIBITION OF CHOLINESTERASES BY COMPLEX DERIVATIVES OF MORPHINE [J].

LANE, AC ;

MACFARLANE, IR ;

MCCOUBREY, A .

BIOCHEMICAL PHARMACOLOGY, 1966, 15 (01) :122-+

[9] PRINCIPLES OF ANTIBODY CATALYSIS [J].

LERNER, RA ;

BENKOVIC, SJ .

BIOESSAYS, 1988, 9 (04) :107-112

[10] MOLECULAR ORDER OF PARTICIPATION OF INHIBITORS (OR ACTIVATORS) IN BIOLOGICAL SYSTEMS [J].

LOFTFIELD, RB ;

EIGNER, EA .

SCIENCE, 1969, 164 (3877) :305-+