THE SYNTHESIS OF NOVEL BIFUNCTIONAL LINKER MOLECULES

被引：6

作者：

BILLINGTON, S ^{[1
]}

MANN, J ^{[1
]}

QUAZI, P ^{[1
]}

ALEXANDER, R ^{[1
]}

EATON, MAW ^{[1
]}

MILLAR, K ^{[1
]}

MILLICAN, A ^{[1
]}

机构：

[1] CELLTECH LTD, SLOUGH SL1 4EN, ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(01)87134-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the synthesis of the novel bifunctional linker molecule 2-methyl, 2-(3-carboxypropyl)-cyclopent-4-en-1,3-dione and various related compounds. These compounds are highly thiol-specific.

引用

页码：5231 / 5236

页数：6

共 4 条

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COX, JPL ;

CRAIG, AS ;

HELPS, IM ;

JANKOWSKI, KJ ;

PARKER, D ;

EATON, MAW ;

MILLICAN, AT ;

MILLAR, K ;

BEELEY, NRA ;

BOYCE, BA .

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[2]

GOLDS EE, 1978, J BIOL CHEM, V253, P8162

[3]

Perrin DD, 1988, PURIFICATION LAB CHE

[4] CONJUGATION OF GLUCOSE-OXIDASE FROM ASPERGILLUS-NIGER AND RABBIT ANTIBODIES USING N-HYDROXYSUCCINIMIDE ESTER OF N-(4-CARBOXYCYCLOHEXYLMETHYL)-MALEIMIDE [J].

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