DEXTRAN SULFATE AND HEPARIN SULFATE INHIBIT PLATELET-ACTIVATING FACTOR-INDUCED PULMONARY-EDEMA

被引:31
作者
HOCKING, D
FERRO, TJ
JOHNSON, A
机构
[1] VET ADM MED CTR,RES SERV,113 HOLLAND AVE,ALBANY,NY 12208
[2] UNION UNIV,DEPT PHYSIOL & CELL BIOL,ALBANY,NY 12208
[3] UNION UNIV,DEPT MED,ALBANY,NY 12208
关键词
SULFATED POLYSACCHARIDES; PULMONARY HEMODYNAMICS; CHARGE;
D O I
10.1152/jappl.1992.72.1.179
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We tested the hypothesis that dextran sulfate and heparin sulfate inhibit platelet-activating factor- (PAF) induced pulmonary edema in the isolated perfused guinea pig lung via a charge-dependent mechanism. Dextran sulfate prevented the changes in pulmonary capillary pressure (Ppc, 7.8 +/- 0.9 vs. 14.0 +/- 0.7 cmH2O), lung weight gain (dW, +0.48 +/- 0.29 vs. +8.41 +/- 2.07 g), and pulmonary edema formation or wet-to-dry weight ratio [(W-D)/D, 6.5 +/- 0.3 vs. 13.2 +/- 2.6] occurring 60 min after PAF infusion (10(-11) M) into an isolated lung. The unsulfated form of dextran had no protective effect [Ppc, dW, and (W-D)/D, 11.9 +/- 1.4 cmH2O, +5.33 +/- 2.18 g, and 11.2 +/- 3.2, respectively]. The unrelated anionic compound, heparin sulfate, also inhibited the PAF response [Ppc, dW, and (W-D)/D, 7.0 +/- 0.5 cmH2O, +0.61 +/- 0.32 g, and 6.1 +/- 0.2, respectively], whereas the partially desulfated form of heparin was not effective in inhibiting PAF-induced edema [Ppc, dW, and (W-D)/D, 15.1 +/- 0.7 cmH2O, +6.07 +/- 1.58 g, and 10.0 +/- 1.2, respectively]. When the metachromatic dye crystal violet was used as an indicator of charge interactions, the sulfated compounds interacted with PAF in vitro. The data indicate that PAF-induced pulmonary edema is inhibited by sulfated polysaccharides, possibly via a charge interaction between negatively charged compounds and PAF.
引用
收藏
页码:179 / 185
页数:7
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