THE COCAINE-INDUCED ELEVATION OF PLASMA-CORTICOSTERONE IS MEDIATED BY ENDOGENOUS CORTICOTROPIN-RELEASING FACTOR (CRF) IN RATS

被引：129

作者：

SARNYAI, Z

BIRO, E

PENKE, B

TELEGDY, G

机构：

[1] ALBERT SZENT GYORGYI MED UNIV,INST PATHOPHYSIOL,SZEGED,HUNGARY

[2] ALBERT SZENT GYORGYI MED UNIV,INST MED CHEM,SZEGED,HUNGARY

来源：

BRAIN RESEARCH | 1992年 / 589卷 / 01期

关键词：

COCAINE; CORTICOSTERONE; CORTICOTROPIN-RELEASING FACTOR;

D O I：

10.1016/0006-8993(92)91176-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of endogenous corticotropin-releasing factor (CRF) in the cocaine-induced corticosterone response was investigated by using the immunoneutralization and receptor blockade of endogenous CRF. Pretreatment with different dilutions (1:5, 1:10 and 1:20, i.c.v.) of CRF antibody and different doses of an antagonist for CRF receptors, alpha-helical CRF9-41 (alpha-h-CRF, 0.001-1.0-mu-g, i.c.v.), dose-dependently prevented the cocaine-induced increase in corticosterone level. These results support the hypothesis that the activation of the hypothalamo-pituitary-adrenal (HPA) axis by cocaine is mediated through the release of endogenous CRF.

引用

页码：154 / 156

页数：3

共 16 条

[1]

BOROWSKY B, 1991, J PHARMACOL EXP THER, V256, P204

[2] COCAINE STIMULATES RAT HYPOTHALAMIC CORTICOTROPIN-RELEASING HORMONE-SECRETION INVITRO [J].