A CHROMOSOME-9 DELETION IN PLASMODIUM-FALCIPARUM RESULTS IN LOSS OF CYTOADHERENCE

被引：22

作者：

KEMP, DJ

THOMPSON, J

BARNES, DA

TRIGLIA, T

KARAMALIS, F

PETERSEN, C

BROWN, GV

DAY, KP

机构：

[1] Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1992年 / 87卷

关键词：

CHROMOSOME DELETION; CYTOADHERENCE; PLASMODIUM-FALCIPARUM; PATHOLOGY; PFEMP1;

D O I：

10.1590/S0074-02761992000700011

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Many lines of Plasmodium falciparum undergo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and the selected cells produce gametocytes The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting that PfFMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.

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页码：85 / 89

页数：5

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