REDESIGNATION OF THE RNASE-D ACTIVITY ASSOCIATED WITH RETROVIRAL REVERSE-TRANSCRIPTASE AS RNASE-H

被引：24

作者：

HOSTOMSKY, Z

HUGHES, SH

GOFF, SP

LEGRICE, SFJ

机构：

[1] CASE WESTERN RESERVE UNIV,SCH MED,DIV INFECT DIS,CLEVELAND,OH 44106

[2] AGOURON PHARMACEUT INC,SAN DIEGO,CA 92121

[3] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21702

[4] COLUMBIA UNIV,DEPT BIOCHEM,NEW YORK,NY 10032

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 03期

关键词：

D O I：

10.1128/JVI.68.3.1970-1971.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In the presence of Mn2+, reverse transcriptase of both human immunodeficiency virus and murine leukemia virus hydrolyzes duplex RNA. However, designating this novel activity RNase D conflicts with Escherichia coli RNase D, which participates in tRNA processing. On the basis of its location in the RNase H domain, we propose that this novel retroviral activity be redesignated RNase H*.

引用

页码：1970 / 1971

页数：2

共 8 条

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