LINKAGE OF ALZHEIMERS-DISEASE TO CHROMOSOME-21 AND CHROMOSOME-19 MARKERS - EFFECT OF AGE-OF-ONSET ASSUMPTIONS

被引：4

作者：

GOLDIN, LR

GERSHON, ES

机构：

[1] Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland

来源：

GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 06期

关键词：

AGE OF ONSET; GENETIC HETEROGENEITY; LINKAGE ANALYSIS; ALZHEIMERS DISEASE;

D O I：

10.1002/gepi.1370100620

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Age of onset heterogeneity in Alzheimer's disease families was modelled by allowing for different liability classes for affected individuals according to their age of onset when calculating lod scores to chromosome 21 and chromosome 19 markers. Linkage to chromosome 21 was supported in the Boston data set, and the method of age correction did not greatly change the lod scores when only affected individuals were analyzed. The location of a gene on chromosome 19 for late age of onset illness was affected by the assumptions about early onset individuals. (C) 1993 Wiley-Liss, Inc.*

引用

页码：449 / 454

页数：6

共 6 条

[1] TRANSMISSION AND AGE-AT-ONSET PATTERNS IN FAMILIAL ALZHEIMERS-DISEASE - EVIDENCE FOR HETEROGENEITY [J].

FARRER, LA ;

MYERS, RH ;

CUPPLES, LA ;

GEORGEHYSLOP, PHS ;

BIRD, TD ;

ROSSOR, MN ;

MULLAN, MJ ;

POLINSKY, R ;

NEE, L ;

HESTON, L ;

VAN BROECKHOVEN, C ;

MARTIN, JJ ;

CRAPPERMCLACHLAN, D ;

GROWDON, JH .

NEUROLOGY, 1990, 40 (03) :395-403

[2]

OTT J, 1992, AM J HUM GENET, V51, P283

[3]

PERICAKVANCE MA, 1991, AM J HUM GENET, V48, P1034

[4] GENETIC-LINKAGE EVIDENCE FOR A FAMILIAL ALZHEIMERS-DISEASE LOCUS ON CHROMOSOME-14 [J].

SCHELLENBERG, GD ;

BIRD, TD ;

WIJSMAN, EM ;

ORR, HT ;

ANDERSON, L ;

NEMENS, E ;

WHITE, JA ;

BONNYCASTLE, L ;

WEBER, JL ;

ALONSO, ME ;

POTTER, H ;

HESTON, LL ;

MARTIN, GM .

SCIENCE, 1992, 258 (5082) :668-671

[5] GENETIC-LINKAGE STUDIES SUGGEST THAT ALZHEIMERS-DISEASE IS NOT A SINGLE HOMOGENEOUS DISORDER [J].

STGEORGEHYSLOP, PH ;

HAINES, JL ;

FARRER, LA ;

POLINSKY, R ;

VAN BROECKHOVEN, C ;

GOATE, A ;

MCLACHLAN, DRC ;

ORR, H ;

BRUNI, AC ;

SORBI, S ;

RAINERO, I ;

FONCIN, JF ;

POLLEN, D ;

CANTU, JM ;

TUPLER, R ;

VOSKRESENSKAYA, N ;

MAYEUX, R ;

GROWDON, J ;

FRIED, VA ;

MYERS, RH ;

NEE, L ;

BACKHOVENS, H ;

MARTIN, JJ ;

ROSSOR, M ;

OWEN, MJ ;

MULLAN, M ;

PERCY, ME ;

KARLINSKY, H ;

RICH, S ;

HESTON, L ;

MONTESI, M ;

MORTILLA, M ;

NACMIAS, N ;

GUSELLA, JF ;

HARDY, JA .

NATURE, 1990, 347 (6289) :194-197

[6]

TANZI RE, 1992, AM J HUM GENET, V51, P273

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