H-7, a protein kinase C inhibitor, inhibits spontaneous tone and spasmogenic responses in normal and sensitized guinea pig trachea

被引：3

作者：

DeDiego, A ^{[1
]}

Cortijo, J ^{[1
]}

Villagrasa, V ^{[1
]}

Perpina, M ^{[1
]}

Morcillo, EJ ^{[1
]}

机构：

[1] UNIV VALENCIA,FAC MED & ODONTOL,DEPT FARMACOL,E-46010 VALENCIA,SPAIN

来源：

GENERAL PHARMACOLOGY | 1995年 / 26卷 / 08期

关键词：

H-7; trachea (guinea pig); smooth muscle (airway); (skinned trachea);

D O I：

10.1016/0306-3623(95)00075-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. H-7, a protein kinase C inhibitor, fully inhibited the spontaneous and stimulated (KCl 20 mM or histamine 0.5 mM) tone of trachea from normal and sensitized guinea pig. 2. H-7 depressed the concentration-contraction curves to KCl, histamine or 5-hydroxytryptamine in epithelium-denuded, indomethacin-treated, trachea from normal and sensitized guinea pigs while responses to CaCl2 (in Ca2+-free K+-depolarized tissues) and acetylcholine were not affected. 3. H-7 (100 mu M) did not depress C2+ (20 mu M)-induced contraction of Triton X-100 skinned trachea. 4. These results suggest the involvement of PKC in the maintenance of spontaneous lone and spasmogenic responses of guinea pig trachea.

引用

页码：1747 / 1755

页数：9

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