AUTOMATED-METHOD SELECTION FOR HPLC ANALYSIS OF DRUGS

被引：6

作者：

DESMET, M

MASSART, DL

机构：

[1] Vrije Universiteit Brussel, Farmaceutisch Instituut, Laarbeeklaan 103, B-1090 Brussels, Belgium

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 1987年 / 6卷 / 10期

关键词：

AUTOMATED METHOD SELECTION - DECISION TREE - FORD ALGORITHM - GRAPH THEORY - OPTIMAL PATH;

D O I：

10.1016/0165-9936(87)87130-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Solving an analytical problem usually requires at least three steps: (1) developing a method, (2) carrying it out and (3) interpreting the data obtained (signal, chemical identity, concentration). The method development step itself consists of two sub-steps: (a) the selection of initial parameters and (b) the optimization of these parameters. Traditionally, chemometrics has paid much attention to the optimization step. Much less has been done on making the initial selection. The present article gives a survey of successive chemometric approaches to this problem.

引用

收藏

页码：266 / 271

页数：6

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