THE BENZODIAZEPINE RECEPTOR IN CULTURED ASTROCYTES FROM GENETICALLY EPILEPSY-PRONE RATS

被引：67

作者：

DUCIS, I

NORENBERG, LOB

NORENBERG, MD

机构：

[1] UNIV MIAMI,DEPT PATHOL D33,POB 016960,MIAMI,FL 33101

[2] UNIV MIAMI,JACKSON MEM HOSP,NEUROPATHOL LAB,MIAMI,FL 33136

[3] VET ADM MED CTR,MIAMI,FL 33101

来源：

BRAIN RESEARCH | 1990年 / 531卷 / 1-2期

关键词：

Astrocyte; Epilepsy; Peripheral-type benzodiazepine receptor;

D O I：

10.1016/0006-8993(90)90793-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy. © 1990.

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页码：318 / 321

页数：4

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