NICOTINE INTERFERES WITH GABA-MEDIATED INHIBITORY PROCESSES IN MOUSE HIPPOCAMPUS

被引：12

作者：

FREUND, RK ^{[1
]}

LUNTZLEYBMAN, V ^{[1
]}

COLLINS, AC ^{[1
]}

机构：

[1] UNIV COLORADO,INST BEHAV GENET,BOULDER,CO 80309

来源：

BRAIN RESEARCH | 1990年 / 527卷 / 02期

关键词：

CA1; Hippocampus; Mouse; Nicotine; Paired pulse; Population spike; Recurrent inhibition; γ-Aminobutyric acid;

D O I：

10.1016/0006-8993(90)91148-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies indicated that the excitatory effects of nicotine may be mediated via interference with GABAergic transmission. Here, several variants of the paired-pulse paradigm were employed to ascertain whether nicotine interferes with endogenous inhibitory circuits in the hippocampus. Nicotine attenuated the inhibition evoked by antidromic (alvear) stimulation in the CA1 region in a concentration-dependent manner (EC50 = 60-75 μM). This same phenomenon was also observed for the GABAA receptor antagonist bicuculline (0.1 μM). Orthodromic-orthodromic paired-pulse paradigms were found to be unsuitable for investigating the effects of epileptogenic agents such as nicotine and bicuculline on endogenous inhibition. © 1990.

引用

页码：286 / 291

页数：6

共 33 条

[1] EPILEPTIFORM BURST AFTERHYPERPOLARIZATION - CALCIUM-DEPENDENT POTASSIUM POTENTIAL IN HIPPOCAMPAL CA1-PYRAMIDAL CELLS [J].