CLINICAL-EXPERIENCE OF ENCAINIDE (MJ-9067) - NEW ANTI-ARRHYTHMIC DRUG

被引：48

作者：

KESTELOOT, H ^{[1
]}

STROOBANDT, R ^{[1
]}

机构：

[1] ST JOZEF HOSP, OOSTENDE, BELGIUM

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 16卷 / 05期

关键词：

duration of dipolarization; encainide; extrasystoles;

D O I：

10.1007/BF00605629

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Encainide is a new anti-arrhythmic drug, which is highly effective against ventricular extrasystoles, both single and coupled, in the dose range of 80-140 mg i.v. Ventricular extrasystoles were abolished in 31 out of 33 cases treated. The drug is also relatively effective against supraventricular extrasystoles, but has little effect on atrial fibrillation. Both subjects with clinically normal hearts and those with ischaemic heart disease have been successfully treated. The drug prolongs the QRS and QT duration. Its effectiveness appears to be of the same order of magnitude and the range of indications similar to those of aprindine and lorcainide. Further study of the drug seems to be warranted. © 1979 Springer-Verlag.

引用

页码：323 / 326

页数：4

共 12 条

[1] BRUTSAERT DL, 1978, EFFECT MJ9067 LIDOCA
[2] BYRNE JE, 1977, J PHARMACOL EXP THER, V200, P147
[3] CARMELIET E, 1978, ARCH INT PHARMACOD T, V231, P104
[4] CARMELIET E, 1974, ACTA CARDIOL, P73
[5] GOMOLL AW, 1977, ELECTROPHYSIOLOGICAL
[6] TIME-DEPENDENT AND VOLTAGE-DEPENDENT INTERACTIONS OF ANTIARRHYTHMIC DRUGS WITH CARDIAC SODIUM CHANNELS
HONDEGHEM, LM
KATZUNG, BG
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 472 (3-4) : 373 - 398
[7] KESTELOOT H, 1974, ACTA CARDIOL, P303
[8] KESTELOOT H, 1977, ARCH INT PHARMACOD T, V230, P225
[9] LASSETER KC, 1977, DRUG THER, P122
[10] MAYOL RF, 1976, DEV RADIO IMMUNOASSA

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