HEPATITIS-B VIRUS AND PRIMARY HEPATOCELLULAR-CARCINOMA - TREATMENT OF HBV CARRIERS WITH PHYLLANTHUS-AMARUS

被引：43

作者：

BLUMBERG, BS ^{[1
]}

MILLMAN, I ^{[1
]}

VENKATESWARAN, PS ^{[1
]}

THYAGARAJAN, SP ^{[1
]}

机构：

[1] UNIV MADRAS,POSTGRAD INST BASIC MED SCI,MADRAS 600005,TAMIL NADU,INDIA

来源：

VACCINE | 1990年 / 8卷

关键词：

hepatitis B virus; hepatocellular carcinoma; Phylanthus amarus; woodchuck hepatitis virus;

D O I：

10.1016/0264-410X(90)90225-B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A viricide capable of eliminating hepatitis B virus (HBV) from chronic carriers should, theoretically, decrease the risk of primary hepatocellular carcinoma. Extracts of Phyllanthus amarus have been shown to inhibit the DNA polymerase of HBV and woodchuck hepatitis virus (WHV) in vitro. Three of four recently infected WHV carriers treated i.p. with P. amarus extract lost WHV, animals infected for ≥3 months showed a decrease in virus levels. Preliminary results in human carriers treated orally with P. amarus for 1 month indicated that ≈ 60% of the carriers lost HBV during the observation period. © 1990.

引用

页码：S86 / S92

页数：7

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