MOTOR RESPONSE TO REPEATED DOPAMINERGIC STIMULATION IN PARKINSONS-DISEASE

被引：12

作者：

OBESO, JA

LUQUIN, MR

GRANDAS, F

VAAMONDE, J

LAGUNA, J

MARTINEZLAGE, JM

机构：

[1] Department of Neurology, Clinica Universitaria, 31080 Pamplona

来源：

CLINICAL NEUROPHARMACOLOGY | 1992年 / 15卷 / 01期

关键词：

PARKINSONS DISEASE; PULSATILE STIMULATION; TOLERANCE;

D O I：

10.1097/00002826-199202000-00011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies giving subcutaneous apomorphine or intravenous levodopa boluses have not found clear evidence of behavioral hyposensitivity to repeated dopaminergic stimulation in Parkinson's disease (PD). Here we analyze that data, and review experimental findings in animal models and our previous experience with parkinsonian patients. We conclude that acute tolerance to pulsatile stimulation is likely to play a role in the pathophysiology of motor fluctuations in PD.

引用

页码：75 / 79

页数：5

共 14 条

[1] INCREASED OR DECREASED LOCOMOTOR RESPONSE IN RATS FOLLOWING REPEATED ADMINISTRATION OF APOMORPHINE DEPENDS ON DOSAGE INTERVAL [J].