TRANSFORMING GROWTH FACTOR-BETA-LIKE ACTIVITY IS SECRETED BY RABBIT RENAL CORTICAL TUBULAR CELLS IN PRIMARY CULTURE

被引：7

作者：

KANDA, S

IGAWA, T

TAIDE, M

NOMATA, K

KANETAKE, H

SAITO, Y

机构：

[1] Department of Urology, Nagasaki University School of Medicine, Nagasaki

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1992年 / 16卷 / 07期

关键词：

D O I：

10.1016/S0309-1651(06)80003-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The activity of an autocrine growth factor in a medium conditioned by cultured rabbit renal cortical tubular cells was investigated. Little stimulatory growth activity for tubular cells was observed in the conditioned medium, and inhibitory activity was seen only in acidified conditioned medium. This factor stimulated the colony formation of NRK 49F cells in soft agar only with epidermal growth factor and inhibited the DNA synthesis of primary cultured rat hepatocytes, and its molecular weight was about 25 KDa. The factor was neutralized by the specific antibody to transforming growth factor (TGF)-ß1. These results indicate that renal tubular epithelial cells can produce latent TGF-ß in primary culture. © 1992 Academic Press Ltd.

引用

页码：613 / 623

页数：11

共 19 条

[1] CELLULAR ACTIVATION OF LATENT TRANSFORMING GROWTH-FACTOR-BETA REQUIRES BINDING TO THE CATION-INDEPENDENT MANNOSE 6-PHOSPHATE INSULIN-LIKE GROWTH-FACTOR TYPE-II RECEPTOR [J].