PENETRATION OF CEPHRADINE INTO HEART-VALVES, SUBCUTANEOUS TISSUE AND MUSCLE OF PATIENTS UNDERGOING OPEN-HEART SURGERY

被引：12

作者：

DASCHNER, FD ^{[1
]}

LANGMAACK, H ^{[1
]}

SPILLNER, G ^{[1
]}

AHMADI, A ^{[1
]}

SCHLOSSER, V ^{[1
]}

机构：

[1] UNIV HOSP FREIBURG,DEPT HOSP EPIDEMIOL,DEPT CARDIAC SURG,FREIBURG,FED REP GER

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1979年 / 5卷 / 06期

关键词：

D O I：

10.1093/jac/5.6.711

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Concentrations of cephradine in heart valves, subcutaneous tissue and muscle were determined in 28 adult patients undergoing open heart surgery.Within 120 min of intravenous injection of 1 g cephradine antibiotic concentrations reached levels of between 1.5 and 8.6 μg/g in subcutaneous tissue and muscle; concentrations in heart valves were even higher varying between 3.8 and 15.0 μg/g at 50 to 140 min following administration of the drug. Cephradine concentrations in heart valves exceeded 8 μg/g for an average of 120 min; this concentration inhibited 91% of 64 Staphylococcus epidermidis and 100% of 69 Staphylococcus aureus strains isolated from wounds and the air of the operating theatre. © 1979, by The British Society for Antimicrobial Chemotherapy.

引用

页码：711 / 715

页数：5

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