MEASUREMENTS OF NITRIC-OXIDE IN BIOLOGICAL-MATERIALS USING A PORPHYRINIC MICROSENSOR

被引：110

作者：

MALINSKI, T ^{[1
]}

TAHA, Z ^{[1
]}

GRUNFELD, S ^{[1
]}

BUREWICZ, A ^{[1
]}

TOMBOULIAN, P ^{[1
]}

KIECHLE, F ^{[1
]}

机构：

[1] W BEAUMONT HOSP,ROYAL OAK,MI 48072

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 279卷 / 01期

关键词：

BIOSENSORS; NITRIC OXIDE; PORPHYRINIC MICROSENSOR;

D O I：

10.1016/0003-2670(93)85075-U

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The application and optimization of a microsensor for in situ measurements of nitric oxide (NO) in biological systems are described. The sensor (diameter 0.5-0.8 mum), exhibiting a response time better than 10 ms and a detection limit of 10 nM, consists of several layers of p-type semiconducting polymeric porphyrin and cation exchanger (Nafion) deposited on a thermally-sharpened carbon fiber. The sensor has been applied to studies of NO release from a single endothelial cell in a pulmonary artery, as well as for the determination of NO in blood.

引用

页码：135 / 140

页数：6

共 18 条

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