SALIVARY ANTIBODIES TO HELICOBACTER-PYLORI - SCREENING DYSPEPTIC PATIENTS BEFORE ENDOSCOPY

被引：93

作者：

PATEL, P ^{[1
]}

MENDALL, MA ^{[1
]}

KHULUSI, S ^{[1
]}

MOLINEAUX, N ^{[1
]}

LEVY, J ^{[1
]}

MAXWELL, JD ^{[1
]}

NORTHFIELD, TC ^{[1
]}

机构：

[1] UNIV LONDON ST GEORGES HOSP,SCH MED,DEPT MED,LONDON SW17 0RE,ENGLAND

来源：

LANCET | 1994年 / 344卷 / 8921期

关键词：

D O I：

10.1016/S0140-6736(94)91899-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diagnostic tests on saliva have advantages compared with those on serum. In 119 consecutive dyspeptic patients referred for endoscopy we developed and validated an enzyme-linked immunosorbent assay to detect salivary immunoglobulins to Helicobacter pylori. Salivary IgG distinguished positive and negative cases (p < 0.0001), but salivary IgA did not. The optimum performance of salivary IgG (85%) was similar to that of serum IgG (90%) and better than that of salivary IgA. Using our assay and a history of regular use of non-steroidal anti-inflammatories in screening patients under 45 years, we detected all peptic ulcers while saving 39% of endoscopies.

引用

页码：511 / 512

页数：2

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