SYNTHESIS AND ANTI-HIV-1 ACTIVITY OF BASE MODIFIED ANALOGS OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE (AZT)

被引：12

作者：

CZERNECKI, S

LEDIGUARHER, T

VALERY, JM

机构：

[1] Université Pierre et Marie Curie, Laboratoire de Chimie des Glucides, .75005, PARIS, T 74

来源：

NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 3-4期

关键词：

D O I：

10.1080/07328319308017833

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogues of AZT have been synthesized by modifications at the 4-position of the base. Two synthetic routes are described. Among the new compounds, 3'-azido-2',3'-dideoxy-4-thiouridine 2b exhibited an unexpectedly marked anti-HIV activity on CEM-Cl13 cell lines.

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页码：369 / 380

页数：12

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