HEXOKINASE BINDING IN ISCHEMIC AND REPERFUSED PIGLET BRAIN

被引：6

作者：

GRAY, SM ^{[1
]}

ADAMS, V ^{[1
]}

YAMASHITA, Y ^{[1
]}

LE, SP ^{[1
]}

GODDARDFINEGOLD, J ^{[1
]}

MCCABE, ERB ^{[1
]}

机构：

[1] BAYLOR COLL MED, DEPT MOLEC & HUMAN GENET, HOUSTON, TX USA

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1994年 / 53卷 / 02期

关键词：

D O I：

10.1006/bmmb.1994.1070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hexokinase catalyzes the first step in cerebral glucose utilization and is a rate-limiting enzyme in glycolysis. Glucose utilization is tightly coupled to cerebral blood dow so that during ischemia the brain has a decreased supply of glucose, as well as oxygen. We studied hexokinase enzymatic activity in a newborn piglet model of ischemia-reperfusion to determine if any changes in the activity or mitochondrial binding of the enzyme occurred. We observed that mitochondrial binding of cortical HK increased from 55 to 71% with ischemia and returned toward control levels, but did not completely recover, after 2 h of reperfusion. (C) 1994 Academic Press, Inc.

引用

页码：145 / 148

页数：4

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