INFLUENCE OF VASOPRESSIN AND RELATED PEPTIDES ON GLYCOGEN-PHOSPHORYLASE ACTIVITY AND PHOSPHATIDYLINOSITOL METABOLISM IN HEPATOCYTES

被引：91

作者：

KIRK, CJ ^{[1
]}

RODRIGUES, LM ^{[1
]}

HEMS, DA ^{[1
]}

机构：

[1] ST GEORGES HOSP,SCH MED,DEPT BIOCHEM,LONDON SW17 0RE,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1979年 / 178卷 / 02期

关键词：

D O I：

10.1042/bj1780493

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relative abilities of seven vasopressin-like peptides to activate hepatic glycogen phosphorylase and stimulate phosphate incorporation into phosphatidylinositol were compared. Although the individual peptides differed in their potencies, the concentrations required to stimulate phosphatidylinositol metabolism were always greater (about 10 times) than those needed to activate phosphorylase. The molecular specificity of the hepatic vasopressin receptor and the role of vasopressin-stimulated phosphatidylinositol turnover are discussed.

引用

页码：493 / 496

页数：4

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