SEDATIVE EFFECTS OF APOMORPHINE IN AN ANIMAL-MODEL OF HUNTINGTONS-DISEASE

被引：10

作者：

SANBERG, PR ^{[1
]}

LEHMANN, J ^{[1
]}

FIBIGER, HC ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,DIV NEUROL SCI,VANCOUVER V6T 1W5,BC,CANADA

来源：

ARCHIVES OF NEUROLOGY | 1979年 / 36卷 / 06期

关键词：

D O I：

10.1001/archneur.1979.00500420059006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The sedative effectiveness of apomorphine in a newly developed animal model of Huntington's disease was examined. The motor responses of rats with kainic acid lesions of the neostriatum to a sedative dose of apomorphine (50 μg/kg) was similar to that observed in intact controls. In contrast, compared to controls, a marked potentiation of the motor stimulant effects of dextroamphetamine was confirmed in the kainic acid-lesioned group. We suggest that the pathological changes underlying the symptoms observed in this animal model and in Huntington's disease do not include abnormalities in presynaptic dopamine receptors in the neostriatum. © 1979, American Medical Association. All rights reserved.

引用

页码：349 / 350

页数：2

共 11 条

[1]

CARROLL BJ, 1977, AM J PSYCHIAT, V134, P785

[2] APOMORPHINE HYDROCHLORIDE-INDUCED IMPROVEMENT IN HUNTINGTONS-CHOREA - STIMULATION OF DOPAMINE RECEPTOR [J].

CORSINI, GU ;

ONALI, P ;

MASALA, C ;

CIANCHETTI, C ;

MANGONI, A ;

GESSA, G .

ARCHIVES OF NEUROLOGY, 1978, 35 (01) :27-30

[3]

CORSINI GU, 1977, S NONSTRIATAL DOPAMI, P645

[4] CLINICAL, NEUROPATHOLOGIC AND PHARMACOLOGIC ASPECTS OF HUNTINGTONS-DISEASE - CORRELATES WITH A NEW ANIMAL-MODEL [J].

COYLE, JT ;

SCHWARCZ, R ;

BENNETT, JP ;

CAMPOCHIARO, P .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY, 1977, 1 (1-2) :13-30

[5]

LAL S, 1973, PSYCHIAT NEUROL NEUR, V76, P113

[6]

MAJ J, 1977, POL J PHARMACOL PHAR, V29, P11

[7] KAINIC ACID LESIONS OF STRIATUM DISSOCIATE AMPHETAMINE AND APOMORPHINE STEREOTYPY - SIMILARITIES TO HUNTINGTONS-CHOREA [J].

MASON, ST ;

SANBERG, PR ;

FIBIGER, HC .

SCIENCE, 1978, 201 (4353) :352-355

[8] AMPHETAMINE-INDUCED LOCOMOTOR-ACTIVITY AND STEREOTYPY AFTER KAINIC ACID LESIONS OF STRIATUM [J].

MASON, ST ;

SANBERG, PR ;

FIBIGER, HC .

LIFE SCIENCES, 1978, 22 (06) :451-459

[9] DUPLICATION OF BIOCHEMICAL CHANGES OF HUNTINGTONS-CHOREA BY INTRASTRIATAL INJECTIONS OF GLUTAMIC AND KAINIC ACIDS [J].

MCGEER, EG ;

MCGEER, PL .

NATURE, 1976, 263 (5577) :517-519

[10] IMPAIRED LEARNING AND MEMORY AFTER KAINIC ACID LESIONS OF STRIATUM - BEHAVIORAL-MODEL OF HUNTINGTON DISEASE [J].

SANBERG, PR ;

LEHMANN, J ;

FIBIGER, HC .

BRAIN RESEARCH, 1978, 149 (02) :546-551

← 1 2 →