STARVATION INDUCED INCREASE IN MUSCLE PROTEIN DEGRADATION IS NON-LYSOSOMAL IN ORIGIN

被引：33

作者：

JENKINS, AB

WHITTAKER, M

SCHOFIELD, PJ

机构：

[1] School of Biochemistry, University of New South Wales, Kensington

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)90218-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence is presented that 20 mM NH4+ specifically inhibits lysosomal protein degradation in rat skeletal muscle in vitro. Using this inhibitor it is shown that the increased muscle proteolysis resulting from 48 hr starvation is non-lysosomal in origin. The implications of this result with respect to the mechanism and selectivity of intracellular protein degradation are discussed. © 1979.

引用

页码：1014 / 1019

页数：6

共 12 条

[1]

Ballard F J, 1977, Essays Biochem, V13, P1

[2]

BALLARD FJ, 1978, P AUST BIOCHEM SOC, V11, P43

[3]

Barrett AJ, 1977, LYSOSOMES LABORATORY, P19

[4]

CANONICO PG, 1969, CYTOBIOS, V1, P23