MALFORMATIONS IN INFANTS OF DIABETIC MOTHERS OCCUR BEFORE THE 7TH GESTATIONAL WEEK - IMPLICATIONS FOR TREATMENT

被引：416

作者：

MILLS, JL

BAKER, L

GOLDMAN, AS

机构：

[1] UNIV PENN, SCH MED, DEPT PHARMACOL, PHILADELPHIA, PA 19174 USA

[2] UNIV PENN, SCH MED, PROGRAM ROBERT WOOD JOHNSON CLIN SCH LABS, PHILADELPHIA, PA 19174 USA

[3] CHILDRENS HOSP, PHILADELPHIA, PA 19104 USA

来源：

DIABETES | 1979年 / 28卷 / 04期

关键词：

D O I：

10.2337/diabetes.28.4.292

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A developmental morphologic approach was used to fix the latest time in development at which the malformations commonly reported in infants of diabetic mothers could occur. Developmental morphologic dating shows that the significantly more common congenital malformations in infants of diabetic mothers occur before the 7th wk of gestation. Any therapeutic intervention aimed at decreasing the incidence of congenital malformations must be instituted during the critical early period.

引用

页码：292 / 293

页数：2

共 22 条

[1] HUMAN FETAL INSULIN METABOLISM EARLY IN GESTATION - RESPONSE TO ACUTE ELEVATION OF FETAL GLUCOSE CONCENTRATION AND PLACENTAL TRANSFER OF HUMAN INSULIN-I-131 [J].