INTERACTION BETWEEN RAPHE DORSALIS AND NUCLEUS BASALIS MAGNOCELLULARIS IN SPATIAL-LEARNING

被引：78

作者：

RIEKKINEN, P ^{[1
]}

SIRVIO, J ^{[1
]}

RIEKKINEN, P ^{[1
]}

机构：

[1] UNIV KUOPIO, DEPT PATHOL, KUOPIO, FINLAND

来源：

BRAIN RESEARCH | 1990年 / 527卷 / 02期

关键词：

Aging; Alzheimer's disease; Interaction; Lesioning; Nucleus basalis magnocellularis; Raphe dorsalis; Spatial navigation;

D O I：

10.1016/0006-8993(90)91156-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared the effects on spatial learning of an ibotenic acid lesion of the nucleus basalis magnocellularis (NBM), a 5,7-dihydroxytryptamine lesion of the raphe dorsalis (RD) and a combined NBM and RD lesion. The RD lesion reduced serotonin levels, and the NBM lesion reduced cholineacetyltransferase (ChAT) activity in the cortex. Although RD lesions alone did not affect spatial learning in the water-maze, the lesion aggravated the spatial navigation deficit produced by NMB lesioning. The current results a functional interaction between the RD and NBM in spatial navigation. © 1990.

引用

页码：342 / 345

页数：4

共 22 条

[1] ELECTROLYTIC, BUT NOT 5,7-DIHYDROXYTRYPTAMINE, LESIONS OF THE NUCLEUS MEDIANUS RAPHE IMPAIR ACQUISITION OF A RADIAL MAZE TASK [J].