INVITRO STUDIES OF ELASTIN FIBRIN BIOMATERIAL DEGRADATION - PRESERVATIVE EFFECTS OF PROTEASE INHIBITORS AND ANTIBIOTICS

被引：7

作者：

COLLET, D

LEFEBVRE, F

QUENTIN, C

RABAUD, M

机构：

[1] UNIV BORDEAUX 2, CEEMASI, INSERM, U306, 146 RUE LEO SAIGNAT, F-33076 BORDEAUX, FRANCE

[2] HOP PELLEGRIN, SERV BACTERIOL, F-33000 BORDEAUX, FRANCE

来源：

BIOMATERIALS | 1991年 / 12卷 / 08期

关键词：

ELASTIN; FIBRIN; PROTEASE INHIBITORS; ANTIBIOTICS;

D O I：

10.1016/0142-9612(91)90027-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The degradability of a new elastin-fibrin material was tested in vitro versus human pancreatic elastase (HPE) and plasmin (PL) activities. It is shown that aprotinine Iniprol(R), a well-known protease inhibitor and Eglin C(R), a new potent inhibitor of HPE, especially when used in synergy, efficiently protected the material. A small amount of specific antibiotics was incorporated into the material. The two products will allow the material to be used in digestive surgery with improved safety.

引用

页码：763 / 766

页数：4

共 18 条

[1] A NEW RECONSTITUTED CONNECTIVE-TISSUE MATRIX - PREPARATION, BIOCHEMICAL, STRUCTURAL AND MECHANICAL STUDIES [J].