STUDY OF HLA ANTIGENS AND HAPLOTYPES IN A POPULATION OF CAUCASIANS WITH ACUTE NON-LYMPHOCYTIC LEUKEMIA

An analysis was performed of the HLA types of 136 Caucasian patients with acute nonlymphocytic leukemia (ANLL). Haplotypes were determined from family typing data for 101 of these patients. No increased prevalence of any A or B locus antigen was found in patients with ANLL when compared to a matched control group. The distribution of antigens in the patients did not differ from their siblings and haplotype distribution did not differ from controls. Long-term survival (>2y) was not associated with any particular HLA antigen or haplotype. The number of homozygotes in the study group was not increased. In this group of patients with ANLL no association could be found between HLA antigens and the development or subsequent course of the disease. © 1979.