A NEW ROUTE TO VINYL FLUORIDES

被引：80

作者：

MCCARTHY, JR

MATTHEWS, DP

EDWARDS, ML

STEMERICK, DM

JARVI, ET

机构：

[1] Merrell Dow Research Institute, Cincinnati, OH 45215

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)97869-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The carbanion of diethyl 1-fluoro-1-(phenylsulfonyl)methanephosphonate (7), generated in situ from fluoromethyl phenyl sulfone (3) undergoes the Horner-Wittig reaction with aldehydes and ketones to yield α-fluoro-α,β-unsaturated sulfones (8). Reductive removal of the phenylsulfonyl group provides a facile two-step route to vinyl fluorides froa 3, where the fluorine source is either KF or DAST. © 1990.

引用

页码：5449 / 5452

页数：4

共 18 条

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