INTERFERON-GAMMA INDUCES IN HUMAN NEUTROPHILS AND MACROPHAGES EXPRESSION OF THE MESSENGER-RNA FOR THE HIGH-AFFINITY RECEPTOR FOR MONOMERIC IGG (FC-GAMMA-R-I OR CD64)

被引：59

作者：

CASSATELLA, MA ^{[1
]}

FLYNN, RM ^{[1
]}

AMEZAGA, MA ^{[1
]}

BAZZONI, F ^{[1
]}

VICENTINI, F ^{[1
]}

TRINCHIERI, G ^{[1
]}

机构：

[1] WISTAR INST,PHILADELPHIA,PA 19104

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 170卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92131-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immune interferon (IFN-γ) induces in human neutrophils accumulation of the mRNA for the high affinity receptor for monomeric IgG (FcγR-I, CD64) with a mechanism that is independent from de novo protein synthesis and from activation of the Na+ H+ antiporter. Monocyte-derived macrophages can also be induced to express high levels of FcγR-I mRNA by IFN-γ, without requirement of protein synthesis. Unlike what is observed in neutrophils, induction by IFN-γ of macrophage FcγR-I mRNA was significantly depressed by the Na+ H+ antiporter inhibitor amiloride. These results indicate that phagocytes' FcγR-I mRNA induction by IFN-γ is regulated by different mechanisms depending on the target cells. © 1990.

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页码：582 / 588

页数：7

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